Cerebral net exchange of Brain-Derived Neurotrophic Factor (BDNF) during experimental systemic inflammation and hypoxaemia in humans

doi:10.1186/1757-7241-17-S2-P6

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Volume 17
Suppl 2

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Taudorf S
Bailey DM
Lundby C
Pedersen BK
Møller K

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Taudorf S
Bailey DM
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Møller K
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This article is part of the supplement: Danish Society for Emergency Medicine: Research Symposium 2009 .

Poster presentation

Cerebral net exchange of Brain-Derived Neurotrophic Factor (BDNF) during experimental systemic inflammation and hypoxaemia in humans

Ronan MG Berg¹ , Sarah Taudorf¹, Damian M Bailey², Carsten Lundby³, Bente Klarlund Pedersen¹^,3 and Kirsten Møller¹^,4

¹Centre of Inflammation and Metabolism, Department of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark

²Neurovascular Research Laboratory, Faculty of Health and Science, University of Glamorgan, UK

³Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark

⁴Departments of Cardiothoracic Anesthesia and Intensive Care Unit 4131, University Hospital Rigshospitalet, Copenhagen, Denmark

author email corresponding author email

from Danish Society for Emergency Medicine: Research Symposium 2009
Copenhagen, Denmark. 26 April 2009

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2009, 17(Suppl 2):P6doi:10.1186/1757-7241-17-S2-P6


Published:	20 August 2009

First paragraph (this article has no abstract)

Sepsis is notably associated with neuronal damage, an effect that may be exacerbated by hypoxaemia. The present study was designed to investigate if this interrelationship involves an effect on brain-derived neurotrophic factor (BDNF), an intrinsic neuroprotective agent which is released from the brain under normophysiological conditions [1]. We hypothesised that experimental systemic inflammation and hypoxaemia would abolish this release.